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Atypical Epstein‐Barr virus infection during and after intermittent FK506 therapy
Author(s) -
AZUMA HIROSHI,
SASAKI KAZUHIRO,
MIYAMOTO KAZUTOSHI,
TANAKA KOUICHI,
KATO HIRONORI,
UEMOTO SHINJI,
OKUNO AKIMASA
Publication year - 1997
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1997.tb03586.x
Subject(s) - medicine , immunology , virus , antigen , immune system , antibody , antibody titer , epstein–barr virus , titer , virology
Atypical Epstein‐Barr virus (EBV) infection developed in a patient under intermittent administration of FK506 (one dose in 10 days) after living‐related liver transplantation. The clinical course was similar to severe chronic active EBV infection syndrome (SCAEBV), which is characterized by extremely high titers of antibody to EBV antigens. The clinical symptoms improved without graft rejection even after the cessation of FK506; however, the titers of antibody to EBV antigens remained at high levels. It was considered that: (i) even intermittent use of FK506 could influence the immune response, which then induced atypical EBV infection similar to SCAEBV; and (ii) the impaired immune response, especially to EBV antigens, remained after complete cessation of FK506.