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Infectious mononucleosis as a disease of early childhood in Japan caused by primary Epstein‐Barr virus infection
Author(s) -
KANEGANE HIROKAZU,
KANEGANE CHIHARU,
YACHIE AKIHIRO,
MIYAWAKI TOSHIO,
TOSATO GIOVANNA
Publication year - 1997
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1997.tb03575.x
Subject(s) - mononucleosis , medicine , virus , pharyngitis , incidence (geometry) , atypical lymphocyte , disease , immunology , epstein–barr virus , white blood cell , tonsillitis , pediatrics , lymphoma , physics , optics
The present study investigated 54 pediatric patients with acute Epstein‐Barr virus (EBV)‐induced infectious mononucleosis (IM) in Japan. Most of the acute cases clustered within the first 5 years of life, and the peak incidence was observed at around 4 years of age. These patients were arbitrarily separated into three age groups (less than 3 years, 3–5 years, and 6–14 years). Fever, pharyngitis, lymphadenopathy and hepatomegaly were detected in more than 80% of all cases. Tonsillitis and splenomegaly were present in about 60% of cases. Skin manifestations and eyelids edema were less often detected in the older age group than in the younger age groups. In addition to an increase of total white blood cell and lymphocyte counts in the peripheral blood, a significant increase in the percentage of CD3 + CD8 + HLA‐DR + T cells was always observed. Epstein‐Barr virus seropositivity increased soon after birth and reached approximately 70% around 3 years of age. Close to 100% of the adult controls were EBV seropositive. The results suggest that EBV‐induced acute IM is a disease of early childhood in Japan.