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Pharmacokinetics of antibiotics in children
Author(s) -
TOYONAGA YOSHIKIYO
Publication year - 1997
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1997.tb03568.x
Subject(s) - medicine , pharmacokinetics , antibiotics , regimen , discontinuation , cephalosporin , minimum inhibitory concentration , pharmacology , drug , dosage form , intensive care medicine , microbiology and biotechnology , biology
In designing the dosage regimen of antibiotics including β‐lactams in the field of pediatrics, the choice of adequate drugs, as well as the dosage and the number of administrations have not been performed exactly. This is possibly because of the extended spectrum of antibacterial activity in recent drugs. Even the timing of discontinuation has not been seriously considered. The present report mainly concentrates on several cephalosporins and demonstrates the pharmacokinetic characteristics of the drugs, and further, describes the difference in pharmacokinetic parameters between age groups. On the other hand, it has been suggested that based on the minimum inhibitory concentration for 80% (MIC 80 ) of antibiotics against subject micro‐organisms, the effective area under the concentration‐time curve, time above MIC 80 and C max /MIC 80 should be considered and the suitability of drug choice, the dosage of suitable drugs, and the number of administrations should be decided. The dosage regimen in the present study was not designed to take into account the effects of sub‐MIC and post‐antibiotic effect. However, for monotherapy, the dosage regimen was designed to maintain the concentration of at least MIC, which is sufficient from the viewpoint of saving life.