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Serum level and gene polymorphism of angiotensin I converting enzyme in Japanese children
Author(s) -
YAMAMOTO KOHSUKE,
KATAOKA SATOSHI,
HASHIMOTO NAOSHI,
KAKIHARA TOSHIO,
TANAKA ATSUSHI,
KAWASAKI TAKUYA,
KIKUCHI TORU,
TAKAHASHI HIDEO,
UCHIYAMA MAKOTO
Publication year - 1997
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1997.tb03546.x
Subject(s) - genotype , allele , angiotensin converting enzyme , medicine , polymorphism (computer science) , polymerase chain reaction , allele frequency , genetics , gene , gene polymorphism , blood pressure , endocrinology , biology
The aim of the present study was to determine the distribution of the insertion/deletion polymorphism of angiotensin I converting enzyme (ACE) gene in Japanese children. In addition, the relationship between this polymorphism and serum ACE levels in the same population were analyzed. Insertion/deletion polymorphism located in intron 16 of the ACE gene was examined by polymerase chain reaction in Japanese children aged 10–15 years. Allele frequencies were 0.64 for the insertion allele and 0.36 for the deletion allele in 122 subjects. No association was found between genotypes in this polymorphism and the level of systolic or diastolic blood pressure. A significant relationship between this polymorphism and serum ACE activity was observed. These results suggest that interindividual variability of serum ACE level is strongly influenced by the ACE genotype as early as in childhood.