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Comparison of specific immunities to varicella‐zoster virus following post‐exposure prophylaxis of varicella by oral acyclovir observed in a family
Author(s) -
ASANO YOSHIZO,
SUGA SADAO,
YOSHIKAWA TETSUSHI
Publication year - 1996
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1996.tb03734.x
Subject(s) - medicine , virology , varicella zoster virus , aciclovir , varicella vaccine , virus , immunology , herpesviridae , immunization , antibody , viral disease
An otherwise healthy 3‐year‐old girl developed severe varicella complicated by aseptic meningitis and received intravenous acyclovir (ACV) therapy. Her two siblings who were susceptible to varicella‐zoster virus (VZV) and closely exposed to VZV in the family received oral ACV (45 or 54 mg/kg per day in four divided doses for 7 days) starting 8 days after onset of the index case for post‐exposure prophylaxis of varicella. They showed only five or seven papules over the body without fever 12 days after onset of the index case, while they had one‐third or half the level of antibody titer and equal sized skin reactions to VZV antigen of the index case 2.5 months later.