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Plasma concentration and acute clinical effects of docarpamine, orally active dopamine prodrug, in infants
Author(s) -
TOMITA HIDESHI,
FUSE SHIGETO,
CHIBA SHUNZO
Publication year - 1996
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1996.tb03523.x
Subject(s) - medicine , blood pressure , dopamine , heart rate , oral administration , creatinine , excretion , prodrug , endocrinology , pharmacology
Currently, there are no data available on the optimal doses and efficacy of docarpamine in infants. In the present study, three doses of docarpamine, 15.0–20.4 (19.0 ± 1.9; mean ± SD) mg/kg per dose every 8 h to 10 infants suffering heart failure. Age and bodyweight were from 1 to 4 (1.4 ± 1) months and 2960–5160 (3350 ± 872) g, respectively. In all infants, plasma concentrations of free dopamine were measured 1, 2 and 3 h after the first administration. Heart rate and systolic blood pressure were examined before and at the same time as the first administration. In seven infants, the 24 h urinary output and urinary excretion of electrolytes and creatinine before and during docarpamine were measured. Peak plasma concentration of free dopamine (ng/mL) was achieved after 1 or 2 h of administration, 0–163.1 (37.9 ± 47.2) and 0–105.0 (37.8 ± 39.3), respectively. The concentration had decreased rapidly by 3 h to 0–34.2 (12.4 ± 11.0). Both heart rate (b.p.m.) and blood pressure (mmHg) tended to increase from 120–154 (140 ± 15) and 56–90 (76 ± 11) to a peak of 124–162 (148 ± 14) and 70–92 (79 ± 8), respectively ( P = 0.197, P = 0.289). There were no significant changes in urinary output or excreta. Oral docarpamine of 15–20 mg/kg per dose can achieve plasma free concentrations of dopamine that increase heart rate and systolic blood pressure.