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The safety of a nitric oxide inhalation system using a conventional infant respirator
Author(s) -
SHIBATA YOSHIHIRO,
OKAMOTO KAZUFUMI,
SATO TOSHIHIDE,
KUKITA ICHIRO,
KIKUTA KOICHI
Publication year - 1996
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1996.tb03457.x
Subject(s) - respirator , medicine , inhalation , nitrogen dioxide , nitric oxide , chemiluminescence , anesthesia , toxicology , chromatography , chemistry , organic chemistry , biology
Attention is becoming increasingly focused on inhalation of nitric oxide (NO) as a selective pulmonary vasodilator. Its metabolite nitrogen dioxide (NO 2 ), however, is a toxic molecule. The purpose of the present study was to evaluate the safety of a NO inhalation system using a conventional infant respirator from the viewpoint of NO 2 production. The NO inhalation system consisted of a standard neonatal ventilator, a neonatal circuit and a test lung. The NO concentration was increased from 0 up to 19 ppm. At each level of NO, the oxygen (O 2 ) concentration was changed from 21 to 100%. The NO and NO 2 concentrations were measured with a chemiluminescence analyzer using a molybdenum converter. The NO 2 concentration was increased when either the O 2 or the NO concentration was increased. The maximum concentration of NO 2 was 0.10 ± 0.02 ppm when the concentrations of NO and O 2 were 19 ppm and 100% respectively. The NO inhalation system, using a conventional infant respirator, can be used safely when monitoring NO and NO 2 concentrations.