Premium
Anti‐neutrophil cytoplasmic antibody for proteinase 3 in a child with polyarteritis nodosa
Author(s) -
ITO YUHEI,
NISHI AKINORI,
SAKAGUCHI MINAKO,
SUZUKI YOSHIHARU,
KANEKO KAZUNARI,
YASUOKA CHIKAI,
TOMITA SABUROU,
KATO HIROHISA
Publication year - 1995
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1995.tb03702.x
Subject(s) - medicine , polyarteritis nodosa , proteinase 3 , cytoplasm , antibody , vasculitis , immunology , pathology , autoantibody , microbiology and biotechnology , biology , disease
We report a case of a 15 year old boy with polyarteritis nodosa associated with antineutrophil cytoplasmic antibody (ANCA) against proteinase 3 (PR3). After months of steroid and immunosuppressant therapy, the symptoms subsided and the polyaneurysms almost disappeared. The levels of anti‐PR3 antibody and of cytokines also decreased. The results indicate that ANCA is a good indicator of this disease activity, and may play some pathogenic role in the disease.