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Helicobacter pylori colonization in children with peptic ulcer disease III. Diagnostic value of the 13 C‐urea breath test to detect gastric H. pylori colonization
Author(s) -
YAMASHIRO YUICHIRO,
OGUCHI SATOSHI,
OTSUKA YOSHIKAZU,
NAGATA SATORU,
SHIOYA TAKEHIRO,
SHIMIZU TOSHIAKI
Publication year - 1995
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1995.tb03677.x
Subject(s) - medicine , helicobacter pylori , gastroenterology , breath test , colonization , amoxicillin , gastritis , antrum , peptic , gastric mucosa , stomach , antibiotics , spirillaceae , peptic ulcer , microbiology and biotechnology , biology
The efficiency of the 13 C‐Urea Breath Test ( 13 C‐UBT) for the detection of Helicobacter pylori colonization in gastric mucosa was evaluated. The 13 C‐UBT was performed in five pediatric and six adult subjects who had had upper gastrointestinal endoscopy within 2 weeks. H. pylori colonization was confirmed in two pediatric and three adult subjects with peptic ulcer combined with antral gastritis, by histological examination of antral biopsy specimens. When an individual with H. pylori colonization ingested a solution containing 13 C‐urea, a significant amount of 13 CO 2 appeared in the respiratory CO 2 within 10 min. The mean cumulative percentage dose of 13 C recovered in the breath over 30 min in the cases with H. pylori colonization was significantly higher than that in those who were not colonized (4.91 vs 0.41, P <0.001). In addition, the effect of antibiotic on the eradication of H. pylori from gastric mucosa was monitored by 13 C‐UBT in two cases. The values of cumulative percentage dose of 13 C over 30 min fell to the same levels as those observed in H. pylori negative subjects after just 2 weeks treatment with amoxicillin; however, positive results were obtained again 1 month after the withdrawal of amoxicillin. In summary, 13 C‐UBT is a simple, reliable, non‐invasive method in the diagnosis of gastric H. pylori colonization especially for pediatric patients.