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Cerebral infarction in acute promyelocytic leukemia at initial presentation
Author(s) -
SAITOH EMI,
SUGITA KENICHI,
KUROSAWA HIDEMITSU,
KUROSAKI MOTOYUKI,
EGUCHI MITSUOKI,
FURUKAWA TOSHIHARU,
NAKAJIMA CHIKAKO,
KOBAYASHI YASUAKI
Publication year - 1995
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1995.tb03411.x
Subject(s) - medicine , disseminated intravascular coagulation , acute promyelocytic leukemia , bone marrow , pathology , magnetic resonance imaging , cerebral infarction , leukemia , platelet , ischemia , gastroenterology , radiology , retinoic acid , biochemistry , chemistry , gene
We report on a 3 year old girl with acute promyelocytic leukemia (APL) with cerebral infarction due to disseminated intravascular coagulation (DIC) at initial presentation. She was hospitalized because of unconsciousness and petechiae on the chest wall and extremities. Cerebral ischemia and infarction were found on computed tomography scan and magnetic resonance imaging. Peripheral bood content was hemoglobin 7.3 g/dL, white blood cells 1.0 × 10 3 cells/μL (31% blasts) and platelet count was 12 × 10 3 cells/μL. Fragmented erythrocytes were frequently observed on May‐Giemsa stained blood smears. Bone marrow aspirates showed normal cellularity, with 60.4% blasts, containing faggot cells. The blasts were positive for peroxidase. Therapy was begun; however, the patient died 1 week after admission.