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Detection of immunodeficiencies and persistent infections by urinary neopterin measurement
Author(s) -
HARA TOSHIRO,
MATSUO MUNEAKI,
TASAKI RYUJI,
MIYAZAKI SUMIO,
BAMBA MASAHIRO
Publication year - 1995
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1995.tb03379.x
Subject(s) - medicine , neopterin , urinary system , intensive care medicine , immunology
We evaluated the clinical significance of measurement of urinary neopterin levels in primary immunodeficiencies and persistent infections exclusively at afebrile or asymptomatic periods. Despite the examinations at afebrile or asymptomatic periods, urinary neopterin levels were elevated in some patients with primary immunodeficiencies and in patients with persistent infections of human immunodeficiency virus (HIV) or Epstein‐Barr virus (EBV). Therefore, urinary neopterin measurement at afebrile periods will be useful as one of the screening tests in the detection of such disorders among children with occasional episodes of infections.