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Effect of valproate and carbamazepine on visual evoked potentials in epileptic children
Author(s) -
YÜKSEL ADNAN,
ŞARSLAN OSMAN,
DEVRANOǦLU KAZIM,
DİRİCAN AHMET,
HATTAT NEŞE,
CENANİ ASIM,
YALÇIN ERDİNÇ
Publication year - 1995
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1995.tb03330.x
Subject(s) - carbamazepine , medicine , visual evoked potentials , anesthesia , central nervous system , anticonvulsant , epilepsy , pediatrics , audiology , psychiatry
The effects of carbamazepine (CBZ) and sodium valproate (SV) monotherapy on visual evoked potentials (VEP) were studied in 18 epileptic children receiving CBZ and nine epileptic children receiving SV. Pattern reversal VEP were determined before the administration of antiepileptic drugs (AED) and 1 year later during which time the patients had received AED. The VEP amplitude showed no consistent changes after 1 year of CBZ and SV therapy, but VEP P‐100 latencies were significantly prolonged after 1 year of CBZ therapy. We conclude that CBZ causes a slowing down of central impulse conduction and that VEP is useful to evaluate the effects of AED within the central nervous system.