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Autoantibodies and CD5 + B cells in childhood onset immune thrombocytopenic purpura
Author(s) -
IYORI HIDEAKI,
FUJISAWA KOHJI,
AKATSUKA JUNICHI
Publication year - 1995
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1995.tb03323.x
Subject(s) - medicine , autoantibody , cd5 , platelet , thrombocytopenic purpura , immunology , antibody , monoclonal antibody , immune system , epitope
We evaluated platelet associated immunoglobulin (PaIg) G, PaIgM, platelet associated autoantibodies to platelet glycoprotein IIb/IIIa (Pa‐GPIIb/IIIa), the percentage of CD5 + B cells and the amount of platelet‐bound anti‐GPIIb/IIIa monoclonal antibody (mAb) in the peripheral blood of 29 patients with childhood onset chronic immune thrombocytopenic purpura (c‐ITP). The percentage of CD5 + B cells ranged from 2 to 8% (4.7 ± 2.0) in control patients and 1 to 18% (6.2 ± 4.2) in the ITP patients. There was no overall significant difference between the two groups, but the percentage of CD5 + B cells in six of the ITP patients was higher than the mean + 2 s.d. of the controls. There was a significant correlation between the percentage of CD5 + B cells and PaIgM (y = 1.73x + 13.4, r = 0.40, P < 0.05). This finding is the basis for the speculation that CD5 + B cells may play an important role in the production of PaIgM in vivo. There was no correlation between the amounts of PaIgG and Pa‐GPIIb/IIIa. This suggests that the amount of PaIgG does not accurately reflect of the amount of Pa‐GPIIb/IIIa. Furthermore, we have demonstrated that autoantibodies to GPIIb/IIIa are directed to more than one epitope.