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Interferon‐α potentiates priming‐dependent FMLP‐induced neutrophil superoxide generation in a patient with chronic myeloid leukemia
Author(s) -
TOMODA TAKASHI,
OKADA TAISUKE,
HISAKAWA HIROAKI,
WAKIGUCHI HIROSHI,
KURASHIGE TAKANOBU
Publication year - 1995
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1995.tb03302.x
Subject(s) - medicine , superoxide , myeloid leukemia , interferon , immunology , priming (agriculture) , neutrophile , interferon γ , leukemia , interferon gamma , cytokine , inflammation , enzyme , biochemistry , chemistry , botany , germination , biology
13 year old girl diagnosed as having chronic myeloid leukemia (CML) was treated with interferon‐α (IFN‐α) alone and 4 months later hematological remission was obtained. In the course of the IFN‐α treatment there was neither infectious sign nor side effects. In this study we have examined the effect of IFN‐α on superoxide O 2 − generation by polymorphonuclear neutrophils (PMN). The PMN of the patient generated less O 2 − than PMN from normal controls. When patient PMN were cultured in the presence of 1000 U/mL IFN‐α, enhancement of the formyl‐methionyl‐leucyl‐phenylalanine induced O 2 − generation following priming with tissue necrosis factor‐α was observed. Over the course of the IFN‐α therapy, such O 2 − generation was gradually restored. It is suggested that CML PMN are in the resting condition in terms of their ability to generate O 2 − and that IFN‐α is effective in inducing O 2 − generation by CML PMN.