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A female infant successfully treated by ganciclovir for congenital cytomegalovirus infection
Author(s) -
FUKUDA SUMIO,
MIYACHI MASANAO,
SUGIMOTO SHIGERU,
GOSHIMA AKIRA,
FUTAMURA MASAHIDE,
MORISHIMA TSUNEO
Publication year - 1995
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1995.tb03300.x
Subject(s) - medicine , ganciclovir , cytomegalovirus , diarrhea , leukopenia , pneumonia , pediatrics , surgery , immunology , herpesviridae , chemotherapy , virus , human cytomegalovirus , viral disease
An 11 month old female infant, diagnosed as having congenital cytomegalovirus (CMV) infection and suffering from pneumonia and intractable diarrhea, was treated with 9‐(1,3‐dihydroxy‐2‐propoxymethyl) guanine (DHPG), intravenously for 8 weeks. Watery diarrhea ceased and pneumonia associated with massive endotracheal aspirates was reduced. No leukopenia, thrombocytopenia or other side effects were observed during the therapy. The clinical findings suggest that DHPG might be an effective and safe agent for the treatment of both intestinal and lower respiratory CMV infection in young infants.