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Recurrent pneumococcal meningitis in a patient with transient IgG subclass deficiency
Author(s) -
OHGA SHOUICHI,
OKADA KENJI,
ASAHI TAKAHIRO,
UEDA KOHJI,
SAKIYAMA YUKIO,
MATSUMOTO SHUZO
Publication year - 1995
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1995.tb03297.x
Subject(s) - medicine , meningitis , subclass , immunology , antibody , diphtheria , pneumococcal vaccine , titer , tetanus , vaccination , streptococcus pneumoniae , immunoglobulin g , pediatrics , antibiotics , microbiology and biotechnology , biology
We report the case of a 3 year old boy who exhibited recurrent serious infections with a transient imbalance of IgG subclass in the second year of life. He suffered from pneumococcal meningitis at 3 months, hepatitis at 9 months, and purulent arthritis at 11 months of age. The second episode of pneumococcal meningitis occurred at 14 months. Serum IgG level was normal for age. Low level of IgG2, undetectable level of IgG4 and negligible level of pneumococcus‐specific IgG1‐G2 antibodies were found. No other primary immunodeficiency was apparent. Serum IgG2‐G4 levels but not pneumococcus‐specific IgG1‐G2 titers increased by the age of 30 months. At that time, he was inoculated with a polyvalent pneumococcal vaccine along with acellular diphtheria‐pertussis‐tetanus vaccine. He acquired the immunity against these agents, and had no episodic infections in the following 2 years. This observation stresses the existence of transient IgG subclass deficiency associated with delayed development of the anti‐polysaccharide antibody response.