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Idiopathic infantile hypercalcemia discovered in the newborn period
Author(s) -
SHIMIZU HIROKO,
KODAMA SOICHI,
TAKEUCHI ATSUKO,
MATUI TADATAKA,
NAKAO HIDETO,
SAKURAI TAKASI,
KOBAYASHI TADASHI
Publication year - 1994
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1994.tb03279.x
Subject(s) - medicine , nephrocalcinosis , hypercalciuria , calcitonin , pathogenesis , endocrinology , vitamin d and neurology , calcium , hypercalcaemia , kidney
We report a male newborn with typical clinical signs of idiopathic infantile hypercalcemia (IIH); that is, hypercalcemia, hypercalciuria, an elfin face and nephrocalcinosis without giving Vitamin D 3 supplementation to the patient. He had been treated with a vitamin D‐free, low calcium milk and rectal administration of exogenous calcitonin (elcatonin). The latter seemed to be more effective as a treatment for IIH. The serum calcium level came within the normal range and the serum 1,25‐dihydroxyvitamin D 3 (1,25[OH] 2 D 3 ) level decreased from 101.5 to 75.6 pg/mL with the treatments mentioned above. These results suggest that a high serum concentration of 1,25(OH) 2 D 3 is part of the pathogenesis of IIH. However, we were not able to clarify the pathogenesis of the high serum concentration of 1,25(OH) 2 D 3 .