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Urinary prolactin excretion in children with renal disease
Author(s) -
FELICE CLAUDIO,
TANAKA TOSHIAKI,
HAYAKAWA K.,
ITOH KATZUMI,
WATANABE TAKAYUKI,
KATSUMATA NORIYUKI,
HIBI ITSURO
Publication year - 1994
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1994.tb03257.x
Subject(s) - medicine , prolactin , urinary system , urine , endocrinology , excretion , renal function , kidney , kidney disease , urology , hormone
The contribution of the kidney to the metabolism of prolactin has not yet been established. In the present study, urinary prolactin concentrations in 30 children with renal disease were measured by a newly devised, highly sensitive, time‐resolved immunofluorometric assay. Median prolactin concentrations in the urine of children with renal disease, were 1.86 pmol/L −1 of urine (range: 0.17–546.31 pmol/L −1 . By stepwise regression analysis, change in urinary prolactin levels as a function of the urinary β 2‐microglobulin concentrations was detected. These results indicate that prolactin urinary excretion in children with renal disease is dependent on the renal proximal tubular function.