Premium
A Ro/SS‐A auto‐antibody positive mother's infant revealed congenital complete atrioventricular block, followed by insulin dependent diabetes mellitus and multiple organ failure
Author(s) -
FUKAZAWA RYUJI,
SEKI TAKASHI,
KAMISAGO MITSUHIRO,
WATANABE MASANORI,
OGAWA SHUNICHI,
YUGE KUNIO,
HIRAYAMA TSUNEO
Publication year - 1994
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1994.tb03216.x
Subject(s) - medicine , diabetes mellitus , antibody , atrioventricular block , heart block , heart failure , insulin , cardiology , endocrinology , pediatrics , immunology , electrocardiography
We experienced a congenital complete atrioventricular block infant who was born from a Ro/SS‐A antibody positive mother. Ro/SS‐A antibody was also found in this baby which was presumed to be mediated by the maternal placenta. Temporary cardiac pacing was required at birth and pacemaker implantation was performed at 9 months. At 11 months of age, the baby fell into shock and experienced multiple organ failure because of diabetes mellitus‐induced coma. The association between congenital complete heart block and the Ro/SS‐A antibody is well known. However, the accompaniment of insulin‐dependent diabetes mellitus has not been reported previously. As the Ro/SS‐A antigen appears in the cytoplasm of many tissues, the possibility of an association between Ro/SS‐A antibody and diabetes mellitus is difficult to deny. We report this rare case to draw attention to the possibility that babies who are born from an Ro/SS‐A antibody positive mother may develop diabetes mellitus as well as congenital complete heart block.