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A case of familial thyroxine binding globulin excess associated with growth hormone deficiency
Author(s) -
NAKAI AKIO,
SHIGEMATSU YOSUKE,
KIKAWA YOSHIHARU,
SUDO MASAKATSU
Publication year - 1994
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1994.tb03211.x
Subject(s) - medicine , endocrinology , triiodothyronine , thyroxine binding globulin , globulin , growth hormone deficiency , hormone , thyroid stimulating hormone , bone age , thyroid , growth hormone
A 7 years 3 months old Japanese boy with familial thyroxine binding globulin (TBG) excess associated with growth hormone (GH) deficiency is reported. The patients height was 106.4 cm (‐ 2.86 s.d.) and his bone age was 5 years and 3 months. He had no goiter and his developmental milestones were normal. The serum thyroid stimulating hormone (TSH) was 2.8 μU/mL, triiodothyronine (T 3 ) 3.1 ng/mL, thyroxine (T 4 ) 23.4 μg/dL and free T 4 1.8 ng/dL. The serum TBG level was beyond 80.0 μg/mL, with normal TSH response to the thyrotropin‐releasing hormone (TRH) test. Familial study revealed that his grandmother, mother, uncle, younger sister and younger brother had high TBG and T 3 levels, thus an X‐linked co‐dominant transmission was suggested. The peak GH responses to insulin and clonidine hydrochloride were 5.8 and 8.2 ng/mL, respectively. The mean nocturnal GH concentration was 2.5 ng/mL. His growth velocity increased from 4.8 to 8.4 cm/year and his serum TBG levels decreased gradually after human growth hormone (hGH) treatment.