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Characterization of renal tubular damage in preterm infants with renal failure
Author(s) -
KOJIMA TAKATSUGU,
SASAITAKEDATSU MISA,
HIRATA YUKIO,
KOBAYASHI YOHNOSUKE
Publication year - 1994
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1994.tb03208.x
Subject(s) - medicine , renal injury , intensive care medicine , kidney
This study attempts to clarify the characteristics of renal tubular damage in preterm infants with renal failure. Sixty‐one neonates (17 term and 44 preterm infants) were divided into three groups: 15 infants with intrinsic renal failure (IRF), five term and 10 preterm; 19 with pre‐renal renal failure (PRF), five term and 14 preterm; and 27 without renal dysfunction (control), seven term and 20 preterm. Urine was collected for an 8 h period on the 2nd or 3rd day of life to determine the following parameters: creatinine clearance (Ccr), fractional excretion of sodium (FENa), urinary N ‐acetyl‐beta‐D‐glucosaminidase (NAG) index and endothelin‐1 (ET‐1) excretion. Parameters of renal tubular function and/or renal tubular damage such as FENa, NAG index and ET‐1 excretion were considered as a useful marker to differentiate IRF from PRF in preterm infants. However, these parameters were significantly elevated in preterm infants with PRF. These findings led us to make the following speculations: (i) renal tubular damage may easily occur in preterm infants; and (ii) there still remains difficulty in differentiation between IRF and PRF using Ccr instead of the fluid challenge test.