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Effect of varicella zoster virus antigen‐antibody complexes on hydrogen peroxide generation by human polymorphonuclear leukocytes
Author(s) -
FUJIWARA TAKASHI,
IHARA TOSHIAKI,
YAMAWAKI KATSUHIRO,
ITO MASAHIRO,
KAMIYA HITOSHI,
SAKURAI MINORU
Publication year - 1994
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1994.tb03198.x
Subject(s) - hydrogen peroxide , medicine , varicella zoster virus , antibody , antigen , virus , virology , monoclonal antibody , receptor , immunology , microbiology and biotechnology , biochemistry , biology
Hydrogen peroxide (H 2 O 2 ) generation by human polymorphonuclear leukocytes (PMN) incubated with varicella zoster virus (VZV) antigen was studied by cytofluorography. Hydrogen peroxide generation was detected in the presence of VZV‐seropositive sera. When seropositive sera were heat‐inactivated, H 2 O 2 generation was reduced. When PMN were pre‐incubated with Leu‐1 1b, a monoclonal antibody to the Fc receptor on PMN, H 2 O 2 generation was also reduced. These results suggest that VZV antigen‐antibody‐complement complexes induce H 2 O 2 generation by PMN after these complexes attach to Fc receptors on PMN.