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Renal impairment in very low birthweight infants following antenatal indomethacin administration
Author(s) -
NISHIKUBO TOSHIYA,
TAKAHASHI YUKIHIRO,
NAKAGAWA YAEKO,
KAWAGUCHI CHIHARU,
NAKAJIMA MITSURU,
ICHIJO MOTOHIKO,
YOSHIOKA AKIRA
Publication year - 1994
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1994.tb03162.x
Subject(s) - medicine , oliguria , gestational age , hyperkalemia , obstetrics , pediatrics , preterm labor , pregnancy , gestation , renal function , biology , genetics
Three cases of neonatal renal insufficiency in very low birthweight (VLBW) infants following repeated antenatal administration of indomethacin to prevent premature labor are reported. Three pregnant women received indomethacin (total doses of 150–850 mg) for 3–14 days from admission until delivery. The gestational ages and birthweights of the infants ranged from 24 to 28 weeks and 612 to 1432 g, respectively. Oliguria, early onset of hyperkalemia and prolonged renal dysfunction occurred after birth. Renal failure did not improve in one infant. Despite the efficacy of indomethacin for tocolysis in premature labor, VLBW infants born after repeated maternal administration near the time of delivery may have developed impairment of the premature kidney.