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Effect of specific immunotherapy in Dermatophagoides pteronyssinus allergic children
Author(s) -
KÖKER ORKIDE,
GUNEŞER SEVAL,
ALTINTAS DERYA,
KOZANOGLU MUSTAFA
Publication year - 1994
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1994.tb03151.x
Subject(s) - medicine , immunoglobulin e , asthma , immunotherapy , eosinophil , expiration , nose , immunology , respiratory system , antibody , surgery , immune system
The effect of immunotherapy on 21 Dermatophagoides pteronyssinus (Dpt)‐sensitive patients (15 children with extrinsic asthma and six children with extrinsic asthma plus allergic rhinitis) aged 8.9±0.71 years was studied. Their subjective and objective respiratory symptom score was recorded before beginning and after the first year of immunotherapy. The respiratory subjective symptoms, such as cough day/night, running nose, sputum production, sneezing, shortness of breath at night and asthma attacks, decreased significantly from pretreatment level ( P < 0.05). The objective symptoms, such as wheezing, dyspnea with prolonged expiration, sibilant rales and retractions score, gradually decreased during treatment ( P < 0.01). Total eosinophil count decreased in 76.2% of patients after immunotherapy ( P < 0.01). While total immunoglobulin E (IgE) decreased in 81% of patients and specific IgE for Dpt decreased in 90.5% of patients, specific IgG for Dpt increased in 76% of patient ( P < 0.001). Our results suggested that rising IgG and falling IgE values do not always coexist in the patients who benefit from immunotherapy.