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A long‐term suppression by α‐interferon of Philadelphia chromosome in children with chronic myelogenous leukemia
Author(s) -
KIKAWA YOSHIHARU,
FUJI YASUSHI,
TAKANO TOMOKO,
SHIGEMATSU YOUSUKE,
SUDO MASAKATSU,
OKAMOTO MASANORI,
MIZUTANI SHUKI
Publication year - 1993
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1993.tb03072.x
Subject(s) - medicine , chronic myelogenous leukemia , philadelphia chromosome , breakpoint cluster region , clone (java method) , bone marrow , interferon , leukemia , immunology , alpha interferon , southern blot , abl , interferon alfa , cancer research , gene , chromosomal translocation , receptor , genetics , biology , tyrosine kinase
An 8 year old girl with adult type Philadelphia (Ph 1 )‐positive chronic myelogenous leukemia received natural α‐interferon therapy in the chronic phase. Complete suppression of the Ph 1 clone of bone marrow cells was achieved after 1 month of therapy, which was determined by disappearance of rearranged breakpoint cluster region (BCR) gene in Southern blot analysis. Complete hematological remission was also attained following 2 months of therapy. Both the suppression and the hematological remission have been sustained for 24 months with α‐interferon. in spite of the detection of the chimeric BCR/ABL mRNA in her bone marrow by polymerase chain reaction assay 12 months after therapy.