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Recombinant human granulocyte colony‐stimulating factor therapy for cyclic neutropenia associated with common variable immunodeficiency
Author(s) -
TSUDA MASAHIKO,
URAKAMI TATSUHIKO,
WATANABE SHUICHIRO,
SHIMIZU HISASHI,
INANA ICHIRO,
KIKKAWA YUMIO,
KITAGAWA TERUO
Publication year - 1993
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1993.tb03021.x
Subject(s) - medicine , neutropenia , granulocyte colony stimulating factor , cyclic neutropenia , recombinant dna , common variable immunodeficiency , immunology , intensive care medicine , chemotherapy , antibody , genetics , gene , biology
A 14 year old boy with common variable immunodeficiency (CVID) had regularly recurring episodes of severe infections independently of the serum γ‐globulin level. Serial blood counts revealed that this patient also had cyclic neutropenia. Recently, recombinant human granulocyte colony‐stimulating factor (rhG‐CSF) was reported to be an effective treatment for this disease. We tried rhG‐CSF therapy for this patient and a prompt increase in the neutrophil count was noted. However, the cyclic alterations and duration of the nadir of the neutrophil count were not altered, which suggested that rhG‐CSF has a variable efficacy in at least some patients with cyclic neutropenia.