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Normal levels of IgG subclass in childhood determined by a sensitive ELISA
Author(s) -
HAYASHIBARA HIROSHI,
TANIMOTO KANAME,
NAGATA IKUO,
HARADA YUICHIRO,
SHIRAKI KAZUO
Publication year - 1993
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1993.tb03019.x
Subject(s) - medicine , subclass , umbilical cord , normal values , venous blood , cord blood , age limit , antibody , pediatrics , immunology , demography , sociology
Normal values of all IgG subclasses were determined using a sensitive ELISA in children aged from newborn to 14 years. The upper and lower limits of normal values of all IgG subclasses were obtained in all the age groups using 29 umbilical cord blood samples from full‐term newborns and 308 venous blood samples from normal infants and children. The trends in the levels of IgG1, IgG2 and IgG3 with age were almost similar to previous reports. IgG4 levels decreased gradually until reaching the lowest level at 7 to 12 months and increased gradually with age, reaching a plateau at 12 to 14 years of age. Thus, the lower limit of serum IgG4 levels was determined using our method.