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Increased type III/I collagen and α 1 (I)/α 2 (l) chain in a bronchopulmonary dysplastic lung
Author(s) -
TOGARI HAJIME,
HASHIMOTO YOKO,
WADA YOSHIRO,
HAYAKAWA TARO
Publication year - 1993
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1993.tb03017.x
Subject(s) - medicine , bronchopulmonary dysplasia , lung , alpha (finance) , cystic fibrosis , trimer , pepsin , type i collagen , pathology , gastroenterology , biochemistry , surgery , enzyme , dimer , construct validity , genetics , physics , chemistry , nuclear magnetic resonance , biology , gestational age , pregnancy , patient satisfaction
The type ratio of collagen III/I and molecule ratio of α 1 (I)/α 2 (I) were analysed in lungs from five infants with bronchopulmonary dysplasia (BPD) and seven control infants. All five BPD lungs showed typical characteristics, with pulmonary fibrosis and irregular cystic formation at postmortem examination. A pepsin digestion technique followed by interrupted gel electrophoresis was performed for the determination and molecular analysis of collagens III and I. The ratio of collagen types III and I were significantly increased in BPD lung ( P < 0.005). The ratio of α 1 (I) and α 2 (I) were also significantly increased in BPD lung ( P < 0.05). It is likely that collagen III is predominantly increased and that the α 1 (I) trimer is formed in the active stage of BPD lungs.