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Two color flow cytometric analysis of lymphocytes in HTLV‐I‐carrier children
Author(s) -
SATO TAKAMI,
YANAGISAWA MASAYOSHI,
MUCHI HIROMU
Publication year - 1993
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1993.tb02997.x
Subject(s) - medicine , flow cytometry , cd8 , immunology , immune system , phenotype , t lymphocyte , microbiology and biotechnology , human leukocyte antigen , lymphocyte subsets , virus , andrology , virology , antigen , genetics , biology , gene
Phenotypic changes in lymphocytes from healthy children with antibody for human T lymphotrophic virus type I (HTLV‐I) were studied using two color flow cytometry. The subjects were high school students within a small district of Kyushu, Japan. In the carrier group, a subset of lymphocytes which expressed CD8 + CD57 + was significantly lower in percentage ( P < 0.01) and in number ( P < 0.05). There was no significant difference between carriers and non‐carriers in the percentage and number of CD4 + Leu8 + cells or CD4 + HLA‐DR + cells. The IgG levels were slightly higher in carriers than in non‐carriers ( P < 0.05). These findings suggest that HTLV‐I‐infected cells may affect the immune system in healthy carrier children.