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Atelosteogenesis Type 3: The First Patient in Japan and a Survivor for more than 1 year
Author(s) -
Kuwashima Shigeko,
Nishimura Gen,
Kikushima Hidemaru,
Tanaka Goro,
Furukawa Toshiharu,
Fujioka Mutuhisa
Publication year - 1992
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1992.tb01004.x
Subject(s) - medicine , pediatrics , medical emergency
We report the first patient of atelosteogenesis type 3 (AO 3 ) in Japan. The patient had multiple craniofacial abnormalities at birth, including ocular hypertelorism, a flat nasal bridge, micrognathia and a cleft palate. There was rhizomelic shortness of the limbs and a club‐foot. The infant had short broad thumbs in the hands similar to those observed in the feet. There were no chromosomal abnormalities. Radiological examination demonstrated striking hypoplasia of the humerus with proximal rounding and distal tapering giving a ‘drumstick’ appearance, ‘S’‐shape configuration of the cervical spine, scoliosis and coronal cleft in the thoracolumbar vertebral bodies. The infant experienced recurrent apnea and persistent severe tracheomalacia, which necessitated tracheostomy at 5 months of age. Despite his multiple skeletal deformities and respiratory problems, this patient survived more than 1 year with motorneuronal developmental delay.