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Alpha‐ and Beta‐adrenergic Receptors in Children with Essential Hypertension
Author(s) -
Uchiyama Makoto,
Hayakawa Hiroshi,
Ogawa Teruyuki
Publication year - 1992
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1992.tb00998.x
Subject(s) - medicine , adrenergic receptor , receptor , essential hypertension , adrenergic , endocrinology , pathogenesis , platelet , alpha (finance) , lymphocyte , blood pressure , surgery , construct validity , patient satisfaction
Platelet α 2 ‐ and lymphocyte β‐adrenergic receptors were examined in eight children aged 10–16 years with essential hypertension, and in 11 age‐matched normotensive children. Both α 2 ‐ and β‐adrenergic receptor concentrations showed no significant differences between children with essential hypertension and normotensive children. According to other studies, physiological fluctuations in catecholamines determine lymphocyte β‐adrenergic receptor concentrations, although down‐regulation in platelet α 2 ‐adrenergic receptors has not been observed. The present findings suggest that there may be no abnormalities in α 2 ‐ and β‐adrenergic receptors in essential hypertension in childhood, although a hyperadrenergic state has been reported to be of some relevance to the pathogenesis of essential hypertension in young adolescents.