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Relationship between Pa O2 and Lung Volume during High Frequency Oscillatory Ventilation
Author(s) -
Suzuki Hiroshi,
Papazoglou Kleoniki,
Bryan A. Charles
Publication year - 1992
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1992.tb00995.x
Subject(s) - medicine , ventilation (architecture) , high frequency ventilation , volume (thermodynamics) , lung volumes , lung , cardiology , mechanical ventilation , thermodynamics , physics
The relationship between oxygenation and lung volume during high frequency oscillatory ventilation (HFOV) was studied. We ventilated anesthetized, tracheostomized adult rabbits that were rendered surfactant‐deficient by lung lavage. Lung volume was measured by the ‘disconnection technique’. In the first experiment, HFOV was commenced after conventional mechanical ventilation (CM V) for 1 hr. In the absence of sustained inflation (SI), oxygenation improved with time during HFOV. In the second experiment, HFOV was instituted after CMV for 4hr. In the absence of SI, all animals expired during the experimental period. In the third experiment we ventilated rabbits for 4 hr and then switched to HFOV. We applied SI first and increased mean airway pressure (MAP) by increments of 2 cmH 2 O every 15 min. However, there was little improvement in Pa O2 despite the use of repeated SI and the increase in MAP. We conclude that oxygenation has a linear relationship to lung volume during HFOV, and that secondary lung injury due to long‐term CMV impairs the response to HFOV. Therefore, it is important to minimize the risk of such secondary injuries before instituting HFOV.