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Comparison of Severity of Viremia and Antibody Responses between Infants and Children with Measles
Author(s) -
Suga Sadao,
Yoshikawa Tetsushi,
Asano Yoshizo,
Nakashima Toshihiko,
Yazaki Takehiko
Publication year - 1992
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1992.tb00979.x
Subject(s) - viremia , medicine , peripheral blood mononuclear cell , measles , antibody , immunology , neutralizing antibody , vaccination , in vitro , biology , biochemistry
Severity of viremia and neutralizing antibody responses were compared between nine young infants ( 10 months) with measles and 18 infants and children ( 11 months) with ordinary measles. Peripheral blood mononuclear cell (PBMC)‐associated viremia was detected between the first day of elevation of fever (day 0) and day 5 of the disease in the former group, whereas PBMC‐associated and cell‐free viremia were detected between day 0 and day 14 in the latter group. The number of infected PBMC during the first 7 days of the disease was 3.22 ± 1.07 (log 10 , mean ± s.d.) per 10 million PBMC in the former group, which was significantly smaller ( P = 0.02) than that of the latter group (4.21 ± 1.18). The former group reached the maximum level of antibody earlier than the latter group.