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Comparison of the Incidence of Intracranial Hemorrhage following Conventional Mechanical Ventilation and High Frequency Oscillation in Beagle Puppies
Author(s) -
Tamura Masanori,
Hishi Toshio,
Ishii Teruyuki,
Wakita Suguru,
Oho Shinichi,
Shibuya Kazuhiko,
Miyasaka Katsuyuki,
Takashima Sachio
Publication year - 1992
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1992.tb00978.x
Subject(s) - medicine , beagle , incidence (geometry) , ventilation (architecture) , mechanical ventilation , oscillation (cell signaling) , high frequency ventilation , anesthesia , meteorology , physics , optics , biology , genetics
Controversy exists as to whether high frequency oscillation (HFO) increases the risk of intraventricular hemorrhage (IVH) compared with conventional mechanical ventilation (CMV). We compared the risk of intracranial hemorrhage after phenylephrine‐induced hypertension, combined with a hypovolemic, hypotensive insult followed by rapid volume replacement in two groups of newborn beagle puppies (one group on a piston pump HFO and the other on CMV). A total of 12 beagle puppies (6 on HFO and 6 on CMV) survived the protocol. Arterial blood gas analysis and arterial blood pressures through the study were of the same magnitude in both groups. The length of time for which the puppies remained hypertensive and hypotensive also did not vary significantly between the groups. Intraventricular hemorrhages were observed in two of six CMV puppies and two of six HFO puppies. One animal in each group had a white matter hemorrhage. Subarachnoid hemorrhages were seen in 4 animals on CMV and 3 on HFO. This study indicated that HFO does not increase the risk of any kind of intracranial hemorrhage, including IVH, in beagle puppies.