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Human Herpesvirus 6 (HHV‐6) Infection in the Central Nervous System
Author(s) -
Yamanishi Koichi,
Kondo Kazuhiro,
Mukai Tetsu,
Kondo Toshio,
Nagafuji Hiroshi,
Kato Tomochika,
Okuno Toshiomi,
Kurata Takeshi
Publication year - 1992
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1992.tb00969.x
Subject(s) - human herpesvirus 6 , medicine , tropism , exanthem , virology , cerebrospinal fluid , saliva , central nervous system , virus , encephalitis , human herpesvirus , immunology , herpesviridae , viral disease , pathology
Human herpesvirus 6 (HHV‐6) was isolated from patients with exanthem subitum (ES) with a high frequency, and it is now believed that this virus causes ES as a primary infection in childhood. HHV‐6 infection is highly prevalent in early childhood and this virus may infect infants through the saliva mainly from mother to child. HHV‐6 has a tropism to CD4+ cells and destroys cells in vitro. Although children recover from ES without any sequelae, neurological symptoms associated with exanthem subitum are often observed, and we could detect HHV‐6 in the cerebrospinal fluid of ES patients. This result suggests that HHV‐6 may invade the central nervous system and cause neurological symptoms.