Premium
IgG Subclass Imbalance in Children with Acute Lymphoblastic Leukemia Receiving Maintenance Chemotherapy
Author(s) -
Wakiguchi Hiroshi,
Fujieda Mikiya,
Hisakawa Hiroaki,
Kubota Haruo,
Matsumoto Kenji,
Kurashige Takanobu
Publication year - 1992
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1992.tb00959.x
Subject(s) - medicine , chemotherapy , subclass , lymphoblastic leukemia , immunology , immunoglobulin g , acute lymphocytic leukemia , leukemia , antibody
Serum levels of IgG subclasses were measured in 18 children with acute lymphoblastic leukemia (ALL) receiving maintenance chemotherapy and in 36 age‐matched controls in order to attempt to analyse the effects of chemotherapy. The IgG subclasses were measured by enzyme linked immunosorbent assay. Serum IgG 1 , IgG 2 and IgG 4 levels in the patients were significantly (p<0.01, p<0.005, p<0.005) lower than in the controls, but serum IgG 3 levels in patients were as high as in controls. Suppression on IgG 2 and IgG 4 were more profound than IgG 1 . In six children, the levels of the IgG subclasses were measured at diagnosis, during maintenance chemotherapy and one year after cessation of chemotherapy. The levels of the four IgG subclasses at diagnosis and after cessation of chemotherapy were as high as those in control children except for the IgG 4 levels in the postchemotherapy group. IgG 2 and IgG 4 may be more susceptible to suppression by chemotherapy than IgG 1 and IgG 3 may not be suppressed by chemotherapy.