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Inherited Deficiency of the Ninth Component of Complement Associated with Streptococcal Infection
Author(s) -
Fujita Mitsue,
Fujita Teizo,
Inai Shinya
Publication year - 1992
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1992.tb00945.x
Subject(s) - medicine , inheritance (genetic algorithm) , complement (music) , complement deficiency , immunology , complement system , genetics , antibody , phenotype , gene , complementation , biology
A 7 year old boy, who presented with streptococcal infection, was found to have a low serum complement level (CH50). The C9 component was undetectable. His CH50 rose to the normal value and remained normal for at least three weeks, but decreased to one‐third of the normal level three months later. Family studies were consistent with a familial C9 deficiency, with autosomal co‐dominant inheritance.