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Long‐Term Treatment in Infantile Choriocarcinoma
Author(s) -
Hongo Teruaki,
Fujii Yuji,
Fukuoka Tetuya,
Lijima Sigeo,
Matsusita Takashi,
Nakagawa Yuichi,
Igarashi Yoshio
Publication year - 1992
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1992.tb00925.x
Subject(s) - medicine , choriocarcinoma , etoposide , cyclophosphamide , methotrexate , melphalan , chemotherapy , human chorionic gonadotropin , chorioepithelioma , surgery , gastroenterology , hormone
The long‐term treatment of a 5 month old boy with precocious puberty secondary to the production of chorionic gonadotropin (hCG) by a choriocarcinoma is described. Of 13 cases of infantile choriocarcinoma reported in the literature, none were successfully treated. The present study describes a partially successful outcome with embolization of a hepatic tumor, irradiation of lung and right submandibular tumors, chemotherapy with methotrexate (MTX), actinomycin D (ACD), cyclophosphamide (CPA) and etoposide (VP16), and splenectomy and hepatic lobectomy. Subsequently, the residual hepatic tumors were treated with high dose melphalan (HDM) followed by reinfusion of unpurged autologous marrow.