Premium
Late Effects of Childhood Acute Leukemia and Its Treatment
Author(s) -
Yamamoto Masao,
Fukunaga Yoshitaka,
Tsukimoto Ichiroh,
Bessho Fumio,
Akatsuka Junichi,
Hosoya Ryohta,
Nakazawa Shinpei,
Sakurai Minoru,
Ueda Kazuhiro,
Miyazaki Sumio,
Yokoyama Masaru,
Mugishima Hideo,
Nishimura Kohzoh
Publication year - 1991
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1991.tb02587.x
Subject(s) - medicine , psychosocial , pediatrics , childhood leukemia , adverse effect , short stature , leukemia , lymphoblastic leukemia , psychiatry
Late effects of childhood acute leukemia and its treatment were studied in 766 patients (684 ALL, 73 ANLL, and 9 others) in Japan who had remained in remission for more than 1 year after their first complete remission. Delayed adverse sequelae involve a wide variety of organs and their functions. Short stature was present in 2.61%, obesity in 3.79%, abnormalities of growth hormone secretion in 1.5%, delayed secondary sex characteristics in 1.5% of males and 0.6% of females, motor disturbances in 1.17%, sensory disturbances in 0.91%, intellectual and learning disabilities in 2.48%, abnormal findings in routine neurologic examinations in 1.31%, EEG abnormalities in 4.30%, brain CT abnormalities in 5.09% and cardiac dysfunction in 1.07%. Various other disorders were seen in 20 patients. Many of these delayed adverse sequelae are caused by or related to central nervous system prophylaxis and systemic combination chemotherapy. The results suggest that it is needed to improve therapeutic methods through the stratification of patients by risk factors and detailed analysis of prognostic factors. Moreover it is important to render medical and psychosocial support to long‐term survivors of childhood leukemia through interactions between the patient, parents and medical staff.