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Angiotensin‐Induced Hypertension Chemotherapy in Children with Advanced Solid Tumors
Author(s) -
Fujii Yuji,
Hongo Teruaki,
Masui Hiroyuki,
Chiba Takako,
Furukawa Nobuko,
Nakajima Hiroaki,
Nasuda Kaoru,
Yajima Shuhei,
Horikoshi Yasuo,
Igarashi Yoshio
Publication year - 1991
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1991.tb01570.x
Subject(s) - medicine , hepatoblastoma , chemotherapy , sarcoma , immunohistochemistry , cancer , oncology , pathology
Angiotensin‐induced hypertension chemotherapy (IHC) was investigated in six children with the following advanced malignancies: hepatocellular carcinoma, extraskeletal Ewing's sarcoma, sacrococcygeal malignant teratoma, small round cell tumor of the chest wall, hepatoblastoma and osteogenic sarcoma. Partial response was achieved in three of these patients, two showed no change, and in one IHC was used as adjuvant chemotherapy. The side effects of IHC were minimal and tolerable. Angiotensin‐IHC may provide a new approach to pediatric cancer chemotherapy.