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Effect of Glucocorticoids on Bone Gla Protein Values ‐BGP as a Good Marker of Osteoporosis‐
Author(s) -
Iwasaki Tetsumi
Publication year - 1991
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1991.tb01559.x
Subject(s) - medicine , osteoporosis , prednisolone , endocrinology , psl , osteocalcin , bone formation , alkaline phosphatase , biology , biochemistry , enzyme , geometry , mathematics
It is important to prevent corticosteroid(CS)‐induced osteoporosis, particularly in children. One of the mechanisms is a direct inhibitory effect of C S on osteoblasts. Bone Gla protein (BGP) is produced in osteoblasts, and the serum level of BGP reflects the bone formation rate. The aim of this study is to examine the usefulness of BGP as a marker of CS‐induced osteoporosis. In the present study, serum levels of 24 pediatric patients who were given prednisolone (PSL) for long periods were studied in relation to their growth rate. Serum BGP was also determined in 167 healthy children and 16 adults. In healthy children, BGP levels reached a peak at the age of 15 years in boys and 11 years in girls. In patients who were given more than 0.25 mg/kg/day PSL, serum BGP levels were significantly decreased and height growth was remarkably suppressed. In conclusion, the measurement of serum BGP is useful for early detection of CS‐induced osteoporosis.