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Antibody Response Determined with Antibody‐Dependent Cell‐Mediated Cytotoxicity (ADCC), Neutralizing Antibody, and Varicella Skin Test in Children with Natural Varicella and After Varicella Immunization
Author(s) -
Ihara Toshiaki,
Kato Takashi,
Torigoe Sadayoshi,
Oitani Kaichi,
Isaji Machiko,
Ito Masahiro,
Kamiya Hitoshi,
Sakura Minoru
Publication year - 1991
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1991.tb01518.x
Subject(s) - antibody dependent cell mediated cytotoxicity , medicine , antibody , humoral immunity , varicella vaccine , virology , immunology , immunity , immunization , cellular immunity , immune system , varicella zoster virus , neutralizing antibody , virus , monoclonal antibody
Humoral and cellular immune responses were examined in 115 children with varicella and in 21 children who had been immunized with live varicella vaccine. Antibody determined with antibody‐dependent cell‐mediated cytotoxicity (ADCC) was detected earlier than neutralizing antibody (NT) in both groups. While humoral and cellular immunity were detected simultaneously in the natural varicella group, cellular immunity was detected earlier than humoral immunity in the immunized group. This suggests that ADCC, rather than NT, is involved in the early stages of recovery from varicella‐zoster virus (VZV) infection.