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The Teratogenic Effects of E‐64 on Rat Embryogenesis
Author(s) -
Tachikura Toshio
Publication year - 1990
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1990.tb00869.x
Subject(s) - exencephaly , microphthalmia , medicine , anophthalmia , embryogenesis , teratology , gestation , fetus , hypoplasia , embryo , hydronephrosis , pregnancy , andrology , endocrinology , biology , urinary system , biochemistry , genetics , gene , microbiology and biotechnology
To examine the effects of E‐64 (a thiol protease inhibitor) on the development of rat embryos, pregnant Wistar rats were injected with 10–30 mgkg of E‐64 intra‐peritoneally on days 9 and 10 of gestation. On day 21, the rats were killed and the fetuses were examined for malformations. When 30 mgkg of E‐64 was administered, the incidence of resorptions and malformations was 25.7% and 60.4%, respectively, The most common malformations were hydrocephaly, exencephaly, anophthalmia, microphthalmia, hydronephrosis and renal hypoplasia. “hew results suggest that thiol protease inhibitor is teratogenic during early rat embryogenesis.