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Pernicious Anemia in a Patient with Hypogammaglobulinemia
Author(s) -
Moriuchi Hiroyuki,
Takayanagi Toshimitsu,
Yamasaki Shiro,
Yasui Makoto,
Mori Koichi,
Yanai Masanori,
Tsuji Yoshiro
Publication year - 1990
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1990.tb00830.x
Subject(s) - medicine , hypogammaglobulinemia , pernicious anemia , anemia , pediatrics , intensive care medicine , dermatology , immunology , antibody
A 19‐year‐old male with pernicious anemia and hypogammaglobulinemia (common variable immunodeficiency: CVID) is reported in comparison with classical pernicious anemia. This case was characterized by an earlier onset of anemia, the absence of autoantibodies to intrinsic factor or gastric parietal cells and involvement of the pyloric antrum as well as the gastric corpus. It is suggested that dysregulation of cellular immunity produces the autoimmune lesion in the gastric mucosa, including the pyloric antrum, in a patient with CVID, and that some of such cases develop pernicious anemia.