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Effects of Intravenous Nitroglycerin on Hemodynamics in Neonates with Refractory Congestive Heart Failure of PFC
Author(s) -
Tamura Masanori,
Kawano Toshio
Publication year - 1990
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1990.tb00827.x
Subject(s) - medicine , heart failure , ventricle , refractory (planetary science) , cardiology , vasodilation , cardiac output , hemodynamics , anesthesia , physics , astrobiology
(1) Continuous intravenous infusion (2–10 μ/kg/min) of nitroglycerin (TNG) was administered to 20 neonates consisting of 17 with refractory congestive heart failure and 3 with PFC (Persistent Fetal Circulation). (2) AT doses of 2–4 μ/kg/min, there were no significant changes in heart rate or systemic blood pressue. (3) At doses of 2–4 μ/kg/min, the CVP was significantly reduced and urnary output increased. (4) Echocardiograms revealed a significant decrease in LVS at 4 – 5 μ/kg/min. In addition, the EF and cardiac output were significantly increased at 2 – 5 μ/kg/min. (5) The right ventricle systolic time interval (STI) was reduced significantly at 2 μ/kg/min. The left ventricle STI was not reduced below doses of 4 μ/kg/min. (6) In the dose range 2 – 5 μ/kg/min, TNG is an effective and safe vasodilator in the treatment of refractory congestive heart failure or PFC in neonates.