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Chemical Mediators in Hypersensitivity Reactions
Author(s) -
Nagakura Toshikazu,
Ebisawa Motohiro,
Reason Donald C.,
Likura Yoji
Publication year - 1990
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1990.tb00813.x
Subject(s) - medicine , vascular permeability , immunology , intracellular , arachidonic acid , delayed hypersensitivity , mechanism (biology) , microbiology and biotechnology , immune system , biochemistry , pathology , enzyme , chemistry , biology , philosophy , epistemology
The study of chemical mediators is essential in clarifying the mechanism of hypersensitivity reactions. Recent advances in this field have been made particularly with the arachidonic acid metabolites, several of which strongly contract smooth muscle, attract granulocytes to inflammatory foci and lead to increased vascular permeability. These functions play a crucial role in allergic reactions. Furthermore these mediators might work to modulate the intracellular netwodc which mediates the complicated inflammatory process of hypersensitivity reactions.