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Pancreatic Hormone Changes in Infantile Obstructive jaundice
Author(s) -
Hata Yoshinobu,
Sasaki Fumiaki,
Igarashi Motomu,
Namieno Tsutomu,
Takahashi Hiromasa,
Uchino Junichi
Publication year - 1990
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1990.tb00780.x
Subject(s) - medicine , glucagon , biliary atresia , obstructive jaundice , ligation , hormone , jaundice , endocrinology , gastroenterology , neonatal hepatitis , hepatic fibrosis , cholestasis , pancreas , atresia , fibrosis , liver transplantation , transplantation
Metabolic disturbances of pancreatic hormones in obstructive jaundice in infancy were evaluated experimentally and clinically. In our experimental study, using young rats, the level of plasma insulin (IRI) gradually increased after ligation of the common bile duct. These levels were a little lower than those in the non‐treated controls. The level of plasma glucagon (IRG) incerased remarkably 4 weeks after ligation of the common bile duct. Clinically, there were no significant differnces in the levels of IRI and IRG among normal controls and cases of neonatal hepatitis and congenital biliary atresia (CBA). In CBA patients, these levels can be correlated with the progression of hepatic fibrosis; an increase in IRG and a decrease in teh IRI/IRG mol ratio was noticed in patients with grade III of hepatic fibrosis. These indicate that, in obstructive jaundice in infancy, the more severe the hepatic damage due to obstructive jaundice, the higher the level of plasma glucagon concentration will rise.