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Intravenous Flunitrazepam for Status Epilepticus
Author(s) -
Sumi Kiyoomi,
Nagaura Tomoaki,
Sakata Naoki,
Nishigaki Toshinori,
Akagi Motohiro
Publication year - 1989
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1989.tb01355.x
Subject(s) - medicine , status epilepticus , flunitrazepam , lorazepam , emergency medicine , anesthesia , epilepsy , intensive care medicine , benzodiazepine , psychiatry , receptor
Flunitrazepam (FZP) was administered intravenously, with success, to two patients with status epilepticus. Case 1 was a patient with a tonicclonic status epilepticus. Intravenous phenytoin had no effect. Case 2 had minor status epilepticus. With the intravenous administration of FZP, diluted 1:10 with distilled water at a dose of 0.03 mg/kg at a slow rate, both patients were relieved of the status epilepticus. Unlike diazepam, FZP neither looks cloudy when diluted with distilled water nor causes angialgia. No disturbances in circulation or respiration occurred. Considering that FZP has a strong anticonvulsant action on status epilepticus, it can be expected to be a useful therapeutic agent for status epilepticus in infants and children.