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Supplementary Thyroxine Therapy in Patients with Hypothyroidism Induced by Long‐Term Anticonvulsant Therapy
Author(s) -
Kodama Soichi,
Tanaka Kazuhiro,
Konishi Hideki,
Momota Keiko,
Nakasako Hirohide,
Nakayama Shinichi,
Yagi Jiro,
Koderazawa Keiko
Publication year - 1989
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1989.tb01354.x
Subject(s) - medicine , endocrinology , anticonvulsant , thyroid , basal (medicine) , pediatrics , gastroenterology , epilepsy , psychiatry , insulin
Of 287 patients under long‐term therapy with anticonvulsants, 24 with low serum thyroxine and free thyroxine concentrations were prescribed supplementary thyroxine in the present study. In addition, the basal metabolic rate (BMR) was measured in 13 out of 24 patients and in eight of them it was low (under ‐15%). Serum thyroid hormone concentrations improved after administration of thyroxine. However, improvement of the BMR was not obtained after one month of supplementary therapy. EEG after administration showed an increase in the power spectra of the occipital alpha 2 band (10.0–12.8 Hz) and beta 1 band (13.0–19.8 Hz), and a decrease in that of the theta band (4.0–7.8 Hz). The inter‐peak latency from wave I to wave V in the ABR was normalized after administration, These results suggest that supplementary therapy with thyroxine may be necessary in patients with hypothyroidism induced by anticonvulsants.