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Syndrome of Resistance to Thyroid Hormone in an Infant with Congenital Cytomegalovirus Infection
Author(s) -
Hirano Takeki,
Jogamoto Mitsuto,
Chin Ishou
Publication year - 1989
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1989.tb01342.x
Subject(s) - medicine , cytomegalovirus , thyroid , hormone , thyroid stimulating hormone , cytomegalovirus infection , endocrinology , physiology , virus , immunology , human cytomegalovirus , herpesviridae , viral disease
We describe an infant with congenital cytomegalovirus infection who developed the syndrome of resistance to thyroid hormone at three weeks of age, presenting with elevated thyroxine levels and non‐suppressible thyroid‐hormone‐stimulating hormone secretions without any features of thyrotoxicosis. The resistance was present at the peripheral and pituitary levels and resolved spontaneously by 18 months of age. Cytomegalovirus infee tion was confmed by the positive urine culture of this virus. This case demonstrates for the fit time a possible association of thyroid hormone resistance with congenital cytomegalovirus infection.